Package: Surrogate
Type: Package
Title: Evaluation of Surrogate Endpoints in Clinical Trials
Version: 0.1-73
Date: 2016-05-16
Author: Wim Van der Elst, Paul Meyvisch, Ariel Alonso, Hannah M. Ensor, Christopher J. Weir & Geert Molenberghs
Maintainer: Wim Van der Elst <Wim.vanderelst@gmail.com>
Description: In a clinical trial, it frequently occurs that the most credible outcome to evaluate the effectiveness of a new therapy (the true endpoint) is difficult to measure. In such a situation, it can be an effective strategy to replace the true endpoint by a (bio)marker that is easier to measure and that allows for a prediction of the treatment effect on the true endpoint (a surrogate endpoint). The package 'Surrogate' allows for an evaluation of the appropriateness of a candidate surrogate endpoint based on the meta-analytic, information-theoretic, and causal-inference frameworks. Part of this software has been developed using funding provided from the European Union's 7-th Framework Programme for research, technological development and demonstration under Grant Agreement no 602552.
Depends: MASS, msm
Imports: rgl, lattice, latticeExtra, survival, nlme, lme4,
        OrdinalLogisticBiplot, logistf, rms, mixtools
License: GPL (>= 2)
BugReports: Wim Van der Elst <Wim.vanderelst@gmail.com>
Repository: CRAN
NeedsCompilation: no
Packaged: 2016-05-16 07:14:28 UTC; WimVDE
Date/Publication: 2016-05-16 14:33:06
